Tramadol 37.5/325mg

Tramadol 37.5mg / Acetaminophen 325mg – Dual-Action Pain Relief | Ultracet® Equivalent

Tramadol 37.5mg / Acetaminophen 325mg is a dual-action prescription pain reliever designed to treat moderate to moderately severe pain. It combines two effective agents:

• Tramadol Hydrochloride (37.5mg) – a centrally acting synthetic opioid that alters pain perception by targeting mu-opioid receptors and inhibiting norepinephrine/serotonin reuptake.

• Acetaminophen (325mg) – a non-opioid analgesic and antipyretic, commonly known as paracetamol, that enhances pain relief and reduces fever by acting on the hypothalamic heat-regulating center.

This combination offers faster, stronger, and safer short-term relief than either medication alone, often prescribed after surgery, injury, dental work, or for chronic musculoskeletal pain.

Chemical & Pharmacological Profile:

• Tramadol HCl (C16H25NO2) – Weak mu-opioid agonist, SNRI-like action

• Acetaminophen (C8H9NO2) – Centrally acting analgesic/antipyretic

• Drug Class: Tramadol – Schedule IV controlled substance (U.S.)

• Mechanism: Modulates CNS pain signals + reduces inflammation

• Onset: 30–60 minutes

• Duration: ~4–6 hours

Common Brand Names:

• Ultracet® – Branded combination by Janssen

• Tramacet® – UK/Europe branding

• Also available as generic Tramadol/Acetaminophen 37.5/325mg from various U.S. and U.K. manufacturers

Medical Uses:

• Moderate to moderately severe pain (acute or chronic)

• Commonly prescribed after:

  • Minor surgeries

  • Dental extractions

  • Musculoskeletal injuries (sprains, arthritis, back pain)

• Not for long-term chronic pain unless supervised by a doctor

Dosage & Administration:

• Standard adult dose: 1–2 tablets every 4 to 6 hours as needed

• Maximum daily dose: 8 tablets (i.e. 300mg Tramadol + 2600mg Acetaminophen)

• Take with or without food

• Do not exceed the acetaminophen limit (max 4000mg/day) to avoid liver damage

Warnings & Side Effects:

• Common: Dizziness, nausea, constipation, drowsiness

• Serious: Liver toxicity (from acetaminophen overdose), dependence (from tramadol), serotonin syndrome (when combined with SSRIs)

• Avoid alcohol, sedatives, or other CNS depressants

• Not for patients with:

  • Severe liver disease

  • History of opioid abuse

  • Concurrent use of MAOIs or seizure disorders

Shipping & Availability:

• Ships to USA, UK, and selected regions

• Available as Ultracet®, generic 37.5/325mg tablets

• Secure checkout, discreet delivery, bulk packs: 30, 60, 90, 120 tablets